Publications

see ORCID

see Pubmed

All publications listed below have undergone peer review.
Original research articles (for review articles and book chapters, see below)

1 Wilhelmsen K, Deshpande A, Tronnes S, Mahanta M, Banicki M, Cochran M, Cowdin S, Fortney K, Hartman G, Hughes RE, Montgomery R, Portillo CP, Rubin P, Salazar T, Wang Y, Yan S, Morgan BA, Duisembekova A, Riou R, Marleaux M, Hochheiser IV, Buthmann H, Ferber D, Torp J, Wang W, Cranston M, McKee CM, Mawhinney TJ, McKay EC, Eroglu FK, Kümmerle-Deschner J, Weber ANR, Py BF, Geyer M, Coll RC. Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action. J Exp Med. 2025. 222:e20242403.
2 Silva de Oliveira R, Shupe A, Krause T, Richardo T, Ohland C, Sabachvili M, Bucher K, Hetzer J, Hörner S, Dauch D, Heikenwälder M, Trautwein C, Weber ANR, Klepsch V, McCoy KD, Mager LF. Bifidobacteria-derived exopolysaccharide promotes anti-tumor immunity. Cell Rep. 2025. 44:116223.
3 Wolf J, Kusche Y, Eroglu FK, Kümmerle-Deschner J, Vogl T, Fritz G, Weber ANR, Jorch SK, Roth J, Austermann J. S100A9 promotes inflammasome-dependent autoinflammation by blocking the degradation of SYK tyrosine kinase. J Leukoc Biol. 2025. 117:qiaf129.
4 Sylvain A, Stoehr N, Ma F, Cernijenko A, Schröder M, Khoshouei M, Vogelsanger M, Schoenboerner M, Burke A, Rao P, Solomon JM, Paulk J, Xu L, Dawson J, Begue D, Lefeuvre P, Ahrne E, Hofmann A, Dickson CJ, Arabin P, Zimmerlin A, Kiffe M, Froehlicher M, Boersig T, Elhajouji A, Brichet M, Menon S, Liu S, Mueller M, Wartchow CA, Lin J, Gloria YC, Dickhöfer S, Weber ANR, Welzel T, Kuemmerle-Deschner J, Farady CJ, Pulz R, Bornancin F, Buckley DL, Bassi ZI. A cereblon-based glue degrader of NEK7 regulates NLRP3 inflammasome in a context-dependent manner. Cell Chem Biol. 2025. 32:955-968.e13.
5 Fischer B, Kolb A, Focaccia E, Kübelbeck T, Klein M, Löck D, Bork F, Engelmann F, Casari M, Mazza E, Deppermann C, Weber ANR, Wittmann M, Schittek B, Schulze-Osthoff K, Kramer D. NOD2-Induced IκBζ Mediates a Protective Host Response against Epicutaneous Staphylococcus aureus Infection. J Invest Dermatol. 2025. S0022-202X(25)00494-4.
6 Engels P, Szolek A, Hörner S, Syrigos GV, Hebbel K, Schmidtke M, Zhou M, Mateo-Tortola M, Schönfeld C, Stefanczyk SA, Wolter K, Babaei S, Schindler M, Claassen M, Dauch D, Zender L, Tapía-Abellán A, Weber ANR. Actionable heterogeneity of hepatocellular carcinoma therapy-induced senescence. Cancer Immunol Immunother. 2025. 74:207.
7 Li N, Deshmukh MV, Sahin F, Hafza N, Ammanath AV, Ehnert S, Nüssler A, Weber ANR, Jin T, Götz F. Staphylococcus aureus thermonuclease NucA is a key virulence factor in septic arthritis. Commun Biol. 2025. 8:598.
8 Chang TH, Cardona Gloria Y, Hellmann MJ, Richardo T, Greve CL, Le Roy D, Roger T, Bork F, Bugl S, Jakob J, Sonnberger J, Kasper L, Hube B, Pusch S, Gow NAR, Sørlie M, Tøndervik A, Moerschbacher BM, Weber ANR. Transkingdom mechanism of MAMP generation by chitotriosidase feeds oligomeric chitin from fungal pathogens and allergens into TLR2-mediated innate immune sensing. Front Immunol. 2025. 16:1497174.
9 Rudalska R, Harbig J, Forster M, Woelffing P, Esposito A, Kudolo M, Botezatu A, Haller V, Janssen N, Holzmayer S, Nahidino P, Trompak O, Pantsar T, Kronenberger T, Yurttas C, Rist E, Weber ANR, Dahlke MH, Ott G, Koenigsrainer A, Rothbauer U, Maerklin M, Muerdter T, Schwab M, Singer S, Zender L, Laufer S, Dauch D. First-in-class ultralong-target-residence-time p38α inhibitors as a mitosis-targeted therapy for colorectal cancer. Nat Cancer. 2025. 6:259-277.
10 Leal VNC, Bork F, Mateo Tortola M, von Guilleaume JC, Greve CL, Bugl S, Danker B, Bittner ZA, Grimbacher B, Pontillo A, Weber ANR. Bruton's tyrosine kinase (BTK) and matrix metalloproteinase-9 (MMP-9) regulate NLRP3 inflammasome-dependent cytokine and neutrophil extracellular trap responses in primary neutrophils. J Allergy Clin Immunol. 2025. 155:569-582.
11 Saller BS, Wöhrle S, Fischer L, Dufossez C, Ingerl IL, Kessler S, Mateo-Tortola M, Gorka O, Lange F, Cheng Y, Neuwirt E, Marada A, Koentges C, Urban C, Aktories P, Reuther P, Giese S, Kirschnek S, Mayer C, Pilic J, Falquez-Medina F, Oelgeklaus A, Deepagan VG, Shojaee F, Zimmermann JA, Weber D, Tai YH, Crois A, Ciminski K, Peyronnet R, Brandenburg KS, Wu G, Baumeister R, Heimbucher T, Rizzi M, Riedel D, Helmstädter M, Buescher J, Neumann K, Misgeld T, Kerschensteiner M, Walentek P, Kreutz C, Maurer U, Rambold AS, Vince JE, Edlich F, Malli R, Häcker G, Kierdorf K, Meisinger C, Köttgen A, Jakobs S, Weber ANR, Schwemmle M, Groß CJ, Groß O. Acute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activation. Immunity. 2025. 58:90-107.e11.
12 Knopp T, Jung R, Wild J, Bochenek ML, Efentakis P, Lehmann A, Bieler T, Garlapati P, Richter C, Molitor M, Perius K, Finger S, Lagrange J, Ghasemi I, Zifkos K, Kommoss KS, Masri J, Reißig S, Randriamboavonjy V, Wunderlich T, Hövelmeyer N, Weber ANR, Mufazalov IA, Bosmann M, Bechmann I, Fleming I, Oelze M, Daiber A, Münzel T, Schäfer K, Wenzel P, Waisman A, Karbach S. Myeloid cell-derived interleukin-6 induces vascular dysfunction and vascular and systemic inflammation. Eur Heart J Open. 2024. 4:oeae046.
13 Bork F, Greve CL, Youn C, Chen S, N C Leal V, Wang Y, Fischer B, Nasri M, Focken J, Scheurer J, Engels P, Dubbelaar M, Hipp K, Zalat B, Szolek A, Wu MJ, Schittek B, Bugl S, Kufer TA, Löffler MW, Chamaillard M, Skokowa J, Kramer D, Archer NK, Weber ANR. naRNA-LL37 composite DAMPs define sterile NETs as self-propagating drivers of inflammation. EMBO Rep. 2024. 25(7):2914-2949.
14 Bayer J, Becker J, Liu X, Gritsch L, Daiber E, Korn N, Oesterhelt F, Fraunholz M, Weber A, Wolz C. Differential survival of Staphylococcal species in macrophages. Mol Microbiol. 2024. 121:470-480.
15 Maia A, Cardona Gloria Y, Fuchs K, Chang TH, Engels P, Zhou M, Hinnenthal T, Rusch E, Gouttefangeas C, Weber ANR. Chitin oligomers promote lymphoid innate and adaptive immune cell activation. J Leukoc Biol. 2023. 114:180-186.
16 Weber ANR, Tapia-Abellán A, Liu X, Aróstegui JI, Pelegrín P, Welzel T, Kuemmerle-Deschner JB. Comment on: Effective ex vivo inhibition of cryopyrin-associated periodic syndrome (CAPS)-associated mutant NLRP3 inflammasome by MCC950/CRID3: Reply. Rheumatology (Oxford). 2023 May 2;62(5):e168-e169.
17 Bhattacharya S, Maupin AJ, Schlosser AG, Füchtbauer EM, Gloria YC, Weber ANR, Holmskov U, Moeller JB, Templeton SP. The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells. PLoS One. 2023 Mar 8;18(3):e0282347.
18 Bellut M, Bieber M, Kraft P, Weber ANR, Stoll G, Schuhmann MK. Delayed NLRP3 inflammasome inhibition ameliorates subacute stroke progression in mice. J Neuroinflammation. 2023. 20:4.
19 Weber ANR, Tapia-Abellán A, Liu X, Dickhöfer S, Aróstegui JI, Pelegrín P, Welzel T, Kuemmerle-Deschner JB. Effective ex vivo inhibition of cryopyrin-associated periodic syndrome (CAPS)-associated mutant NLRP3 inflammasome by MCC950/CRID3. Rheumatology (Oxford). 2022. 61:e299-e313.
20 Baranašić J, Šutić M, Catalano C, Drpa G, Huhn S, Majhen D, Nestić D, Kurtović M, Rumora L, Bosnar M, Vukić Dugac A, Sokolović I, Popovic-Grle S, Oršolić N, Škrinjarić-Cincar S, Jakopović M, Samaržija M, Weber ANR, Försti A, Knežević J. TLR5 Variants Are Associated with the Risk for COPD and NSCLC Development, Better Overall Survival of the NSCLC Patients and Increased Chemosensitivity in the H1299 Cell Line. Biomedicines. 2022. 10:2240.
21 Kazmierski J, Elsner C, Döhner K, Xu S, Ducroux A, Pott F, Jansen J, Thorball CW, Zeymer O, Zhou X, Fedorov R, Fellay J, Löffler MW, Weber ANR, Sodeik B, Goffinet C. A Baseline Cellular Antiviral State Is Maintained by cGAS and Its Most Frequent Naturally Occurring Variant rs610913. J Immunol. 2022. 209:535-547.
22 Bellut M, Bieber M, Kraft P, Weber ANR, Stoll G, Schuhmann MK. Delayed NLRP3 inflammasome inhibition ameliorates subacute stroke progression in mice. J Neuroinflammation. 2023 Jan 4;20(1):4. doi: 10.1186/s12974-022-02674-w.
23 Weber ANR, Tapia-Abellán A, Liu X, Aróstegui JI, Pelegrín P, Welzel T, Kuemmerle-Deschner JB. Comment on: Effective ex vivo inhibition of cryopyrin-associated periodic syndrome (CAPS)-associated mutant NLRP3 inflammasome by MCC950/CRID3: Reply. Rheumatology (Oxford). 2022 Dec 23:keac718. doi: 10.1093/rheumatology/keac718.
24 Kazmierski J, Elsner C, Döhner K, Xu S, Ducroux A, Pott F, Jansen J, Thorball CW, Zeymer O, Zhou X, Fedorov R, Fellay J, Löffler MW, Weber ANR, Sodeik B, Goffinet C. A Baseline Cellular Antiviral State Is Maintained by cGAS and Its Most Frequent Naturally Occurring Variant rs610913. J Immunol. 2022 Jul 18:ji2100685. doi: 10.4049/jimmunol.2100685.
25 Baranašić J, Šutić M, Catalano C, Drpa G, Huhn S, Majhen D, Nestić D, Kurtović M, Rumora L, Bosnar M, Vukić Dugac A, Sokolović I, Popovic-Grle S, Oršolić N, Škrinjarić-Cincar S, Jakopović M, Samaržija M, Weber ANR, Försti A, Knežević J. TLR5 Variants Are Associated with the Risk for COPD and NSCLC Development, Better Overall Survival of the NSCLC Patients and Increased Chemosensitivity in the H1299 Cell Line. Biomedicines. 2022 Sep 9;10(9):2240. doi: 10.3390/biomedicines10092240.
26 Weber ANR, Tapia-Abellán A, Liu X, Dickhöfer S, Arostegui JI, Pelegrin P, Welzel T, Kümmerle-Deschner J. Effective ex vivo inhibition of Cryopyrin-Associated Periodic Syndrome (CAPS)-associated mutant NLRP3 inflammasome by MCC950/CRID3. Rheumatology (Oxford). 2022 May 17:keac273. doi: 10.1093/rheumatology/keac273.
27 Kumpf O, Gürtler K, Sur S, Parvin M, Zerbe LK, Eckert JK, Weber ANR, Oh DY, Lundvall L, Hamann L, Schumann RR. A Genetic Variation of Lipopolysaccharide Binding Protein Affects the Inflammatory Response and Is Associated with Improved Outcome during Sepsis. Immunohorizons. 2021;5(12):972-982. doi: 10.4049/immunohorizons.2100095.
28 Bittner ZA, Liu X, Mateo Tortola M, Tapia-Abellán A, Shankar S, Andreeva L, Mangan M, Spalinger M, Kalbacher H, Düwell P, Lovotti M, Bosch K, Dickhöfer S, Marcu A, Stevanović S, Herster F, Cardona Gloria Y, Chang TH, Bork F, Greve CL, Löffler MW, Wolz OO, Schilling NA, Kümmerle-Deschner JB, Wagner S, Delor A, Grimbacher B, Hantschel O, Scharl M, Wu H, Latz E, Weber ANR. BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity. J Exp Med. 2021;218(11):e20201656.
29 Münzer P, Negro R, Fukui S, di Meglio L, Aymonnier K, Chu L, Cherpokova D, Gutch S, Sorvillo N, Shi L, Magupalli VG, Weber ANR, Scharf RE, Waterman CM, Wu H, Wagner DD. NLRP3 Inflammasome Assembly in Neutrophils Is Supported by PAD4 and Promotes NETosis Under Sterile Conditions. Front Immunol. 2021; 12:683803.
30 Cardona Gloria Y, Bernhart SH, Fillinger S, Wolz OO, Dickhöfer S, Admard J, Ossowski S, Nahnsen S, Siebert R, Weber ANR. Absence of Non-Canonical, Inhibitory MYD88 Splice Variants in B Cell Lymphomas Correlates With Sustained NF-κB Signaling. Front Immunol. 2021;12:616451.
31 Franke M, Bieber M, Kraft P, Weber AN, Stoll G, Schuhmann M. The NLRP3 inflammasome drives inflammation in ischemia/reperfusion injury after transient middle cerebral artery occlusion in mice. Brain, Behavior, and Immunity 2020;S0889-1591(20)32452-1.
32 Bitschar K, Staudenmaier L, Klink L, Focken J, Sauer B, Fehrenbacher B, Herster F, Bittner Z, Bleul L, Schaller M, Wolz C, Weber ANR, Peschel A, Schittek B. Staphylococcus aureus Skin Colonization Is Enhanced by the Interaction of Neutrophil Extracellular Traps with Keratinocytes. J Invest Dermatol 2020;140(5):1054-1065.
33 Kuemmerle-Deschner J, Welzel T, Hoertnagel K, Tsiflikas I, Hospach A, Liu X, Schlipf S, Hansmann S, Samba SD, Griesinger A, Benseler SM, Weber AN. New variant in the IL1RN-gene (DIRA) associated with late-onset, CRMO-like presentation. Rheumatology (Oxford) 2020;59(11):3259-3263.
34 Catalano C, da Silva Filho MI, Frank C, Lu S, Jiraskova K, Vymetalkova V, Levy M, Liska V, Vycital O, Naccarati A, Vodickova L, Hemminki K, Vodicka P, Weber AN, Försti A. Epistatic effect of TLR3 and cGAS-STING-IKKε-TBK1-IFN signaling variants on colorectal cancer risk. Cancer Med 2020;9(4):1473-1484.
35 Herster F, Bittner Z, Archer NK, Dickhöfer S, Eisel D, Eigenbrod T, Knorpp T, Schneiderhan-Marra N, Löffler MW, Kalbacher H, Vierbuchen T, Heine H, Miller LS, Hartl D, Freund L, Schäkel K, Heister M, Ghoreschi K, Weber ANR. Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis. Nat Commun 2020; 11(1):105.
36 Rammensee HG, Wiesmüller KH, Chandran PA, Zelba H, Rusch E, Gouttefangeas C, Kowalewski DJ, Di Marco M, Haen SP, Walz JS, Gloria YC, Bödder J, Schertel JM, Tunger A, Müller L, Kießler M, Wehner R, Schmitz M, Jakobi M, Schneiderhan-Marra N, Klein R, Laske K, Artzner K, Backert L, Schuster H, Schwenck J, Weber ANR, Pichler BJ, Kneilling M, la Fougère C, Forchhammer S, Metzler G, Bauer J, Weide B, Schippert W, Stevanović S, Löffler MW. A new synthetic toll-like receptor 1/2 ligand is an efficient adjuvant for peptide vaccination in a human volunteer.  Immunother Cancer 2019;7(1):307
37 El Maadidi S*, Weber ANR*, Motshwene P, Schüssler JM, Backes D, Dickhöfer S, Wang H, Liu X, Garcia MD, Taumer C, Soufi B, Wolz OO, Klimosch SN, Franz-Wachtel M, Macek B, Gay NJ. Putative link between Polo-like kinases (PLKs) and Toll-like receptor (TLR) signaling in transformed and primary human immune cells. Sci Rep. 2019 Sep 11;9(1):13168. *equal contribution.
38 Herster F, Bittner Z, Codrea MC, Archer NK, Heister M, Löffler MW, Heumos S, Wegner J, Businger R, Schindler M, Stegner D, Schäkel K, Grabbe S, Ghoreschi K, Miller LS, Weber ANR. Platelets Aggregate With Neutrophils and Promote Skin Pathology in Psoriasis. Front Immunol. 2019;10:1867. doi: 10.3389/fimmu.2019.01867. eCollection 2019.
39 Steimle A, Menz S, Bender A, Ball B, Weber ANR, Hagemann T, Lange A, Maerz JK, Parusel R, Michaelis L, Schäfer A, Yao H, Löw HC, Beier S, Tesfazgi Mebrhatu M, Gronbach K, Wagner S, Voehringer D, Schaller M, Fehrenbacher B, Autenrieth IB, Oelschlaeger TA, Frick JS. Flagellin hypervariable region determines symbiotic properties of commensal Escherichia coli strains. PLoS Biol. 2019 Jun 17;17(6):e3000334.
40 Hafner A, Kolbe U, Freund I, Castiglia V, Kovarik P, Poth T, Herster F, Weigand MA, Weber ANR, Dalpke AH, Eigenbrod T. Crucial Role of Nucleic Acid Sensing via Endosomal Toll-Like Receptors for the Defense of Streptococcus pyogenes in vitro and in vivo. Front Immunol. 2019 Feb 21;10:198. doi: 10.3389/fimmu.2019.00198. eCollection 2019.
41 Catalano C, da Silva Filho MI, Frank C, Jiraskova K, Vymetalkova V, Levy M, Liska V, Vycital O, Naccarati A, Vodickova L, Hemminki K, Vodicka P, Weber ANR, Försti A. Investigation of single and synergic effects of NLRC5 and PD-L1 variants on the risk of colorectal cancer. PLoS One. 2018 Feb 6;13(2):e0192385. doi: 10.1371/journal.pone.0192385. eCollection 2018.
42 Fuchs K*, Cardona Gloria Y*, Wolz OO, Herster F, Sharma L, Dillen C, Täumer C, Dickhöfer D, Bittner Z, Dang TM, Singh A, Haischer D, Schlöffel MA, Koymans KJ, Sanmuganantham T, Krach M, Schilling NA, Frauhammer F, Miller L, Nürnberger N, LeibundGut-Landmann S, Gust AA, Macek B, Frank M, Gouttefangeas C, Dela Cruz CS, Hartl DH, Weber AN. The fungal ligand chitin directly binds TLR2 and triggers inflammation dependent on oligomer size. EMBO Rep 2018 Oct 18. pii: e201846065. doi: 10.15252/embr.201846065.
43 Boudesco C, Verhoeyen E, Martin L, Chassagne-Clement C, Salmi L, Mhaidly R, Pangault C, Fest T, Ramla S, Jardin F, Wolz OO, Weber ANR, Garrido C, Jego G. HSP110 sustains chronic NF-κB signaling in activated B-cell diffuse large B-cell lymphoma through MyD88 stabilization. Blood. 2018 Aug 2;132(5):510-520. doi: 10.1182/blood-2017-12-819706.
44 Catalano C, da Silva Filho MI, Jiraskova K, Vymetalkova V, Levy M, Liska V, Vycital O, Naccarati A, Vodickova L, Hemminki K, Vodicka P, Weber ANR, Försti A. Influence of regulatory NLRC5 variants on colorectal cancer survival and 5-fluorouracil-based chemotherapy. Eur J Gastroenterol Hepatol. 2018 Aug;30(8):838-842.
45 Huhn S, da Silva Filho MI, Sanmuganantham T, Pichulik T, Catalano C, Pardini B, Naccarati A, Polakova-Vymetálkova V, Jiraskova K, Vodickova L, Vodicka P, Löffler MW, Courth L, Wehkamp J, Din FVN, Timofeeva M, Farrington SM, Jansen L, Hemminki K, Chang-Claude J, Brenner H, Hoffmeister M, Dunlop MG, Weber ANR, Försti A. Coding variants in NOD-like receptors: An association study on risk and survival of colorectal cancer. PLoS One. 2018 Jun 21;13(6):e0199350. doi: 10.1371/journal.pone.0199350. eCollection 2018.
46 Ellwanger K, Becker E, Kienes I, Sowa A, Postma Y, Cardona Gloria Y, Weber ANR, Kufer TA. The NLR family pyrin domain-containing 11 protein contributes to the regulation of inflammatory signaling. J Biol Chem. 2018 Feb 23;293(8):2701-2710.
47 Nurjadi D, Heeg K, Weber ANR, Zanger P. Toll-like receptor (TLR) -9 promotor polymorphisms and gene expression are associated with persistent Staphylococcus aureus nasal carriage. Clin Microbiol Infect. 2018 Feb 16. pii: S1198-743X(18)30187-3.
48 Catalano C, da Silva Filho MI, Frank C, Jiraskova K, Vymetalkova V, Levy M, Liska V, Vycital O, Naccarati A, Vodickova L, Hemminki K, Vodicka P, Weber ANR, Försti A. Investigation of single and synergic effects of NLRC5 and PD-L1 variants on the risk of colorectal cancer. PLoS One. 2018 Feb 6;13(2):e0192385.
49 Fischer J, Weber ANR, Böhm S, Dickhöfer S, El Maadidi S, Deichsel D, Knop V, Klinker H, Möller B, Rasenack J, Wang L, Sharma M, Hinrichsen H, Spengler U, Buggisch P, Sarrazin C, Pawlita M, Waterboer T, Wiese M, Probst-Müller E, Malinverni R, Bochud PY, Gardiner C, O'Farrelly C, Berg T. Sex-specific effects of TLR9 promoter variants on spontaneous clearance of HCV infection. Gut. 2017 Oct;66(10):1829-1837.
50 Stadler N, Hasibeder A, Aranda Lopez P, Desuki A, Kriege O, Weber AN, Michel C, Teschner D, Heß D, Radsak MP.  The Bruton tyrosine kinase inhibitor ibrutinib abrogates TREM-1 mediated neutrophil activation. Haematologica. 2017 May;102(5):e191-e194.
51 Liu X, Pichulik T, Wolz OO, Dang TM, Stutz A, Dillen C, Delmiro Garcia M, Kraus H, Dickhöfer S, Daiber E, Münzenmayer L, Wahl S, Rieber N, Kümmerle-Deschner J, Yazdi A, Franz-Wachtel M, Macek B, Radsak M, Vogel S, Schulte B, Walz JS, Hartl D, Latz E, Stilgenbauer S, Grimbacher B, Miller L, Brunner C, Wolz C, Weber AN. Human NLRP3 inflammasome activity is regulated by and therapeutically targetable via BTK. J Allergy Clin Immunol. 2017 Feb 16. pii: S0091-6749(17)30232-4
52 Murthy P, Durco F, Miller-Ocuin JL, Takedai T, Shankar S, Liang X, Liu X, Cui X, Sachdev U, Rath D, Lotze MT, Zeh III HJ, Gawaz M, Weber AN, Vogel S. The NLRP3 inflammasome and Bruton's tyrosine kinase in platelets co-regulate platelet activation, aggregation, and in vitro thrombus formation. Biochem Biophys Res Commun. 2017 Jan 29;483(1):230-236.
53 Teofilović NK, Bihi M, Stojković MR, Tumir LM, Ester K, Kralj M, Majhen D, Oršolić N, Lepur A, Vrbanec D, Markotić A, Dembić Z, Weber AN, Piantanida I, Vugrek O, Diken M, Knežević J. 1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro. Bioorg Med Chem Lett. 2017 Apr 1;27(7):1530-1537.
54 Dossang AC, Motshwene PG, Yang Y, Symmons MF, Bryant CE, Borman S, George J, Weber AN, Gay NJ. The N-terminal loop of IRAK-4 death domain regulates ordered assembly of the Myddosome signalling scaffold. Sci Rep. 2016 Nov 23;6:37267.
55 Nelde A, Stickel JS, Kowalewski D, Schuster H, Wolz OO, Peper J, Cardona Gloria Y, Langerak A, Muggen A, Claus R, Bonzheim I, Fend F, Salih H, Kanz L, Rammensee HG, Stevanović S, and Weber AN. HLA class I-restricted MYD88 L265P-derived peptides as specific targets for lymphoma immunotherapy. Oncoimmunology. 2016 Dec 23;6(3):e1219825.
56 Fischer J, Weber AN$, Böhm S, Dickhöfer S, El Maadidi S, Deichsel D, Knop V, Klinker H, Möller B, Rasenack J, Wang L, Sharma M, Hinrichsen H, Spengler U, Buggisch P, Sarrazin C, Pawlita M, Waterboer T, Wiese M, Probst-Müller E, Malinverni R, Bochud PY, Gardiner C, O’Farrelly C, Berg T$. Sex-specific effects of TLR9 promoter variants on spontaneous clearance of HCV infection. Gut. 2017 Oct;66(10):1829-1837. $ shared senior authorship.
57 Knittel G, Liedgens P, Korovkina D, Seeger J, Al-Baldawi Y, Al-Maarri M, Fritz C, Vlantis K, Bezhanova S, Scheel AH, Wolz OO, Reimann M, Möller P, López C, Schlesner M, Lohneis P, Weber AN, Trümper L, ICGC MMML-Seq Consortium, Staudt LM, Ortmann L, Pasparakis M, Siebert R, Schmitt CA, Klatt AR, Wunderlich FT, Schäfer SC, Persigehl T, Montesinos-Rongen M, Odenthal M, Büttner R, Frenzel LP, Kashkar H, Reinhardt HC.  B cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B cell lymphoma in mice. Blood. 2016 Jun 2;127(22):2732-41.
58 Wang H, El Maadidi S, Fischer J, Grabski E, Dickhöfer S, Klimosch S, Flannery SM, Filomena A, Wolz OO, Schneiderhan-Marra N, Löffler MW, Wiese M, Pichulik T, Müllhaupt B, Semela D, Dufour J-F, the East-German and Swiss Hepatitis C Virus Study Groups, Bochud P-Y, Bowie AG, Kalinke U, Berg T, Weber AN. A frequent hypofunctional IRAK2 variant is associated with reduced spontaneous hepatitis C virus clearance. Hepatology. 2015 Nov;62(5):1375-87.
59 Pichulik T, Khatamzas E, Liu X, Brain O, Delmiro Garcia M, Leslie A, Danis B, Mayer A, Baban D, Ragoussis J, Weber AN, Simmons A. Pattern recognition receptor mediated downregulation of microRNA-650 fine-tunes MxA expression in dendritic cells infected with influenza A virus. Eur J Immunol. 2015 Oct 8. doi: 10.1002/eji.201444970.
60 Rieber N, Singh A, Öz H, Carevic M, Bouzani M, Amich J, Ost M, Ye Z, Ballbach M, Schäfer I, Mezger M, Klimosch SN, Weber AN, Handgretinger R, Krappmann S, Liese J, Engeholm M, Schüle R, Salih HR, Marodi L, Speckmann C, Grimbacher B, Ruland J, Brown GD, Beilhack A, Loeffler J, Hartl D. Pathogenic fungi regulate T-cell immunity by inducing neutrophilic myeloid-derived suppressor cells through a Dectin-1/CARD9 and ROS-mediated mechanism. Cell Host Microbe. 2015 Apr 8;17(4):507-14.
61 Avbelj M, Wolz OO, Fekonja O, Benčina M, Repič M, Mavri J, Krüger J, Schärfe C, Delmiro-Garcia M, Panter G, Kohlbacher O, Weber AN$, Jerala R$. Activation of lymphoma-associated MyD88 mutations via allostery-induced TIR domain oligomerization. Blood. 2014 Dec 18;124(26):3896-904. $ shared senior authorship.
62 Wang H, Flannery SM, Dickhöfer S, Huhn S, George J, Kubarenko AV, Lascorz J, Bevier M, Willemsen J, Pichulik T, Schafmayer C, Binder M, Manoury B, Paludan SR, Alarcon-Riquelme M, Bowie AG, Försti A, Weber AN. A coding IRAK2 variant compromises TLR signaling and is associated with colorectal cancer survival. J Biol Chem. 2014. 289(33):23123-31.
63 Colak E, Leslie A, Zausmer K, Khatamzas E, Kubarenko AV, Pichulik T, Klimosch SN, Mayer A, Siggs O, Hector A, Fischer R, Klesser B, Rautanen A, Frank M, Hill AVS, Manoury B, Beutler B, Hartl D, Simmons A, Weber AN. RNA and Imidazoquinolines are sensed by distinct TLR7/8 ectodomain sites resulting in functionally disparate signaling events. J Immunol. 2014;192(12):5963-73.
64 Novikova L, Czymmeck N, Deuretzbacher A, Buck F, Richter K, Weber AN, Aepfelbacher M, Ruckdeschel K. Cell death triggered by Yersinia enterocolitica identifies processing of the proinflammatory signal adapter MyD88 as a general event in the execution of apoptosis. J Immunol. 2014 Feb 1;192(3):1209-19.
65 Klimosch SN, Försti A, Eckert J, Knežević J, Bevier M, von Schönfels W, Heits N, Walter J, Hinz S, Lascorz J, Hampe J, Hartl D, Frick JS, Hemminki K, Schafmayer C, Weber AN. Functional TLR5 genetic variants affect human colorectal cancer survival. Cancer Res 2013;73(24):7232-42.
66 Eckert KJ, Kim YJ, Kim JI, Gürtler K, Oh D-Y, Sur S, Lundvall L, Hamann L, van der Ploeg A, Pickkers P, Giamarellos-Bourboulis E, Kubarenko AV, Weber AN, Kabesch M, Kumpf O, An H-J, Lee J-O and Schumann RR. The Crystal Structure of Lipopolysaccharide Binding Protein Reveals the Location of a Frequent Mutation that Impairs Innate Immunity. Immunity 2013; 39(4):647 – 660.
67 Over B, Ziegler S, Foermer S, Weber AN, Bode K, Heeg K and Bekeredjian-Ding I. IRAK4 turns IL-10+ phospho-FOXO+ monocytes into pro-inflammatory cells by suppression of protein kinase B. Eur J Immunol. 2013 Jun;43(6):1630-42.
68 Paquette N, Conlon J, Sweet C, Rus F, Wilson L, Pereira A, Rosadini CV, Goutagny N, Weber AN, Lane WS, Shaffer SA, Maniatis S, Fitzgerald KA, Stuart L, Silverman N. Serine/threonine acetylation of TGFβ-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12710-5.
69 Knežević J, Pavlinić D, Bendelja K, Gabrilovac J, Parcina M, Kubarenko AV, Petricevic B, Vrbanec D, Bulat-Kardum L, Bekeredjian-Ding I, Pavelić J, Dembić Z, Weber AN. Heterozygous Carriage of a Dysfunctional Toll-like Receptor 9 Allele Affects CpG Oligonucleotide Responses in B Cells. J Biol Chem. 2012 Jul 13;287(29):24544-53.
70 Berger M, Hsieh CY, Bakele M, Marcos V, Rieber N, Kormann M, Mays L, Hofer L, Neth O, Vitkov L, Krautgartner WD, von Schweinitz D, Kappler R, Hector A, Weber A, Hartl D. Neutrophils express distinct RNA receptors in a non-canonical way. J Biol Chem. 2012 Jun 1;287(23):19409-17.
71 Lenci R, Rachakonda S, Kubarenko AV, Weber AN, Brandt A, Gast A, Sucker A, Hemminki K, Schadendorf D, Kumar R. Integrin Genes and Susceptibility to Human Melanoma. Mutagenesis 2012 May;27(3):367-73.
72 Gast A, Bermejo JL, Claus R, Brandt A, Weires M, Weber A, Plass C, Sucker A, Hemminki K, Schadendorf D, Kumar R. Association of inherited variation in toll-like receptor genes with malignant melanoma susceptibility and survival. PLoS One. 2011;6(9):e24370.
73 Shatnyeva OM, Kubarenko AV, Weber CE, Pappa A, Schwartz-Albiez R, Weber AN, Krammer PH, Lavrik IN. Modulation of the CD95-Induced Apoptosis: The Role of CD95 N-Glycosylation. PLoS One. 2011;6(5):e19927.
74 Iavarone C, Ramsauer K, Kubarenko AV, Debasitis JC, Leykin I, Weber AN, Siggs OM, Beutler B, Zhang P, Otten G, D'Oro U, Valiante NM, Mbow ML, Visintin A. A point mutation in the amino terminus of TLR7 abolishes signaling without affecting ligand binding. J Immunol. 2011 Apr 1;186(7):4213-22.
75 Sytnikova Y, Kubarenko A, Schäfer A, Weber AN, Niehrs C. Gadd45a is an RNA binding protein and is localized in nuclear speckles. PLoS One. 2011 Jan 7 7;6(1):e14500.5
76 George J, Motshwene G, Wang H, Kubarenko A, Rautanen A, Mills TC, Hill AVS, Weber AN. Death domain assembly in the MyD88-IRAK4-Myddosome is altered in two naturally occurring human MYD88 variants, S34Y and R98C. J Biol Chem 2011, Jan 14;286(2):1341-53.
77 Gdynia G, Keith M, Kopitz J, Bergmann M, Fassl A, Weber AN, George J, Kees T, Zentgraf HW, Wiestler OD, Schirrmacher P, Roth W. Danger signaling protein HMGB1 induces a distinct form of cell death accompanied by formation of giant mitochondria. Cancer Res. 2010 Nov 1;70(21):8558-68.
78 Kubarenko A, Ranjan S, Rautanen, A, Mills TC, Wong S, Vannberg F, Neumaier M, Bekeredjian-Ding I, Hill AVS, Ahmad-Nejad P, Weber AN. A naturally occurring variant in human TLR9, P99L, is associated with loss of CpG oligonucleotide responsiveness. J Biol Chem. 2010 Nov 19;285(47):36486-94.
79 George J, Kubarenko A, Rautanen, A, Mills TC, Colak E, Kempf T, Hill AVS, Nieters A, Weber AN. Mal D96N is a naturally occurring loss-of-function variant of TIRAP. J Immunol. 2010, Mar 15; 184(6): 3025-32.
80 Kubarenko A, Ranjan S, Colak E, George J, Frank M, Weber AN. Comprehensive Modeling and Functional Analysis of Toll-like Receptor Ligand-Recognition Domains. Protein Sci. 2010 Jan 13;19(3):558-569.
81 Shia AK, Glittenberg M, Thompson G, Weber AN, Reichhart JM, Ligoxygakis P. Toll-dependent antimicrobial responses in Drosophila larval fat body require Spatzle secreted by haemocytes. J Cell Sci. 2009 Dec 15;122(Pt 24):4505-15.
82 Pothlichet J, Burtey A, Kubarenko A, Caignard G, Solhonne B, Tangy F, Ben-Ali M, Quintana-Murci L, Heinzmann A, Chiche JD, Vidalain PO, Weber AN, Chignard M, Si-Tahar M. Study of human RIG-I polymorphisms identifies two variants with an opposite impact on the antiviral immune response. PLoS One. 2009 Oct 27;4(10):e7582.
83 Peter M, Kubarenko, A, Weber AN$, Dalpke, A$. Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNA-mediated receptor activation. J Immunol. 2009 Jun 15;182(12):7690-7. $ shared senior authorship.
84 Gangloff M. Murali A. Xiong J. Arnot CJ. Weber AN. Sandercock AM. Robinson CV. Sarisky R. Holzenburg A. Kao C. Gay NJ. Structural insight into the mechanism of activation of the Toll receptor by the dimeric ligand Spätzle. J Biol Chem. 2008. 283(21):14629-35.
85 Kubarenko A. Frank M. Weber AN. Structure Function Relationships of Toll-Like Receptor Domains through Homology Modeling and Molecular Dynamics. Biochem Soc Trans 2007. 35: 1515-8.
86 Tanji T. Hu X. Weber AN. Ip YT. Toll and IMD pathways synergistically activate an innate immune response in Drosophila melanogaster. Mol Cell Biol. 2007. 27:4578-88.
87 Weber AN. Moncrieffe MC. Gangloff M. Imler JL. Gay NJ. Role of the Spätzle pro-domain in the generation of an active Toll receptor ligand. J Biol Chem 2007; 282: 13522-13531.
88 Wang L. Weber AN. Atilano ML. Filipe SR. Gay NJ. Ligoxygakis P. Sensing of Gram-positive bacteria in Drosophila: GNBP1 is needed to process and present peptidoglycan to PGRP-SA. EMBO J. 2006; 25:5005-14.
89 Weber AN. Moncrieffe MC. Gangloff M. Imler JL. Gay NJ. Ligand-receptor and receptor-receptor interactions act in concert to activate signaling in the Drosophila Toll pathway. J Biol Chem. 2005;280(24):22793-9.
90 Weber AN. Morse MA. Gay NJ. Four N-linked glycosylation sites in human Toll-like receptor 2 cooperate to direct efficient biosynthesis and secretion. J Biol Chem. 2004; 279: 34589 – 34594.
91 Weber AN. Tauszig-Delamasure S. Hoffmann JA. Lelievre E. Gascan H. Ray KP. Morse MA. Imler JL. Gay NJ. Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling. Nature Immunology 2003;4(8):794-800.
Reviews and Book Chapters
# Publication
92 Weber ANR, Rosenstiel P. You (bacteria) shall not pass: NLRP6 can sense you! EMBO J. 2025 Nov 20. doi: 10.1038/s44318-025-00638-3.
93 Weber ANR, McManus RM, Hornung V, Geyer M, Kuemmerle-Deschner JB, Latz E. The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets. Nat Immunol. 2025. 26:1453-1466.
94 Weber ANR, Tortola MM, Kuemmerle-Deschner JB. Cracking the NLRP3 code: Pioneering precision medicine for inflammation. J Exp Med. 2024. 221:e20240221.
95 Cardona Gloria Y, Weber ANR. Inflammasome Activation in Human Macrophages: IL-1β Cleavage Detection by Fully Automated Capillary-Based Immunoassay. Methods Mol Biol. 2023. 2696:239-256.
96 Weber ANR. Fish TLR5 develops a taste for viral RNA.  EMBO Rep. 2022 Aug 3;23(8):e55443. doi: 10.15252/embr.202255443.
97 Shankar S, Bittner ZA, Weber ANR. NLRP3 Phospho-residue mapping by phospho dot blots. Methods Mol Biol. 2022; 2459:93-103. doi: 10.1007/978-1-0716-2144-8_10.
98 Weber ANR. Targeting the NLRP3 Inflammasome via BTK. Front Cell Dev Biol. 2021;9:630479.
99 Herster F, Chatterjee M, Karbach S, Weber AN. Platelets – underestimated regulators of auto-inflammation in psoriasis. J Invest Dermatol 2021; 141(6):1395-1403
100 Weber ANR, Bittner ZA, Shankar S, Liu X, Chang TH, Jin T, Tapia-Abellán A. Recent insights into the regulatory networks of NLRP3 inflammasome activation. J Cell Sci. 2020; 133(23):jcs248344.
101 Weber ANR, Cardona Gloria Y, Çınar Ö, Reinhardt HC, Pezzutto A, Wolz OO. Oncogenic MYD88 mutations in lymphoma: novel insights and therapeutic possibilities. Cancer Immunol Immunother. 2018. doi: 10.1007/s00262-018-2242-9.
102 Wolz OO, Koegl M, Weber ANR. Examining Myddosome Formation by Luminescence-Based Mammalian Interactome Mapping (LUMIER). Methods Mol Biol. 2018;1714:119-130.
103 Weber ANR, Bittner Z, Liu X, Dang TM, Radsak MP, Brunner C. Bruton's Tyrosine Kinase: An Emerging Key Player in Innate Immunity. Front Immunol. 2017 Nov 8;8:1454.
104 Gasteiger G, D’Osualdo A, Schubert D, Weber AN, Bruscia E, Hornung V, Hartl D. Cellular innate immunity: new players – old questions. J Innate Immun. 2017;9(2):111-125.
105 Mack I, Hector A, Ballbach M, Kohlhäufl J, Fuchs KJ, Weber A, Mall MA, Hartl D.
The role of chitin, chitinases, and chitinase-like proteins in pediatric lung diseases. Mol Cell Pediatr. 2015 Dec;2(1):3. doi: 10.1186/s40348-015-0014-6.
106 Krüger P. Saffarzadeh M. Weber AN. Rieber N. Radsak M. von Bernuth H Roos D. Skokowa J. Hartl D. Neutrophils: between host defence. immune modulation and tissue injury. PLoS Pathog. 2015 Mar 12;11(3):e1004651.
107 Weber AN. Försti A. Toll-like receptor genetic variants and colorectal cancer. OncoImmunology 2014 Jan 1;3(1):e27763.
108 Gay NJ. Gangloff M. Weber AN. Toll-like receptors as molecular switches. Nature Reviews Immunology. 2006; 6:693-8.
109 Gangloff M. Weber AN. Gay NJ. Conserved mechanisms of signal transduction by Toll and Toll-like receptors. J Endotoxin Res. 2005. 11:294-8.
110 Gay NJ. Weber AN. Gangloff M. Activation of insect and vertebrate toll signaling: from endogenous cytokine ligand to direct recognition of pathogen patterns. Adv Exp Med Biol. 2005. 560:19-27.
111 Gangloff M. Weber AN. Gibbard RJ. Gay NJ. Evolutionary relationships. but functional differences. between the Drosophila and human Toll-like receptor families. Biochem Soc Trans. 2003. 31:659-63.