Publications

Gwenzi T, Weber ANR, Trares K, Vlaski T, Slavic M, Sha S, Dominic E, Caspari R, Bilsing B, Fischer H, Fernandes-Almeida CM, Czock D, Schöttker B, Brenner H. Effects of personalized vitamin D3 on inflammation in colorectal cancer patients: a randomized trial. Br J Cancer. 2026 Jan 8. doi: 10.1038/s41416-025-03333-6. Online ahead of print. PMID: 41507560.

Fischer B, Kolb A, Focaccia E, Kübelbeck T, Klein M, Löck D, Bork F, Engelmann F, Casari M, Mazza E, Deppermann C, Weber ANR, Wittmann M, Schittek B, Schulze-Osthoff K, Kramer D. NOD2-Induced IκBζ Mediates a Protective Host Response against Epicutaneous Staphylococcus aureus Infection. J Invest Dermatol. 146(1):184-197. PMID: 40412468

Weber ANR, Rosenstiel P. You (bacteria) shall not pass: NLRP6 can sense you! EMBO J. 2026. 45(1):1-3. PMID: 41266654.

2025

Saller BS, Wöhrle S, Fischer L, Dufossez C, Ingerl IL, Kessler S, Mateo-Tortola M, Gorka O, Lange F, Cheng Y, Neuwirt E, Marada A, Koentges C, Urban C, Aktories P, Reuther P, Giese S, Kirschnek S, Mayer C, Pilic J, Falquez-Medina H, Oelgeklaus A, Deepagan VG, Shojaee F, Zimmermann JA, Weber D, Tai YH, Crois A, Ciminski K, Peyronnet R, Brandenburg KS, Wu G, Baumeister R, Heimbucher T, Rizzi M, Riedel D, Helmstädter M, Buescher J, Neumann K, Misgeld T, Kerschensteiner M, Walentek P, Kreutz C, Maurer U, Rambold AS, Vince JE, Edlich F, Malli R, Häcker G, Kierdorf K, Meisinger C, Köttgen A, Jakobs S, Weber ANR, Schwemmle M, Groß CJ, Groß O. Acute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activation. Immunity. 2025. 58:90-107.e11. PMID: 39571574

Rudalska R, Harbig J, Forster M, Woelffing P, Esposito A, Kudolo M, Botezatu A, Haller V, Janssen N, Holzmayer S, Nahidino P, Trompak O, Pantsar T, Kronenberger T, Yurttas C, Rist E, Weber ANR, Dahlke MH, Ott G, Koenigsrainer A, Rothbauer U, Maerklin M, Muerdter T, Schwab M, Singer S, Zender L, Laufer S, Dauch D. First-in-class ultralong-target-residence-time p38α inhibitors as a mitosis-targeted therapy for colorectal cancer. Nat Cancer. 2025. 6:259-277. PMID: 39820127

Weber ANR, McManus RM, Hornung V, Geyer M, Kuemmerle-Deschner JB, Latz E. The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets. Nat Immunol. 2025.26(9):1453-1466. PMID: 40826276 Review.

Silva de Oliveira R, Shupe A, Krause T, Richardo T, Ohland C, Sabachvili M, Bucher K, Hetzer J, Hörner S, Dauch D, Heikenwälder M, Trautwein C, Weber ANR, Klepsch V, McCoy KD, Mager LF. Bifidobacteria-derived exopolysaccharide promotes anti-tumor immunity. Cell Rep. 2025. 44:116223. PMID: 40892540.

Sylvain A, Stoehr N, Ma F, Cernijenko A, Schröder M, Khoshouei M, Vogelsanger M, Schoenboerner M, Burke A, Rao P, Solomon JM, Paulk J, Xu L, Dawson J, Begue D, Lefeuvre P, Ahrne E, Hofmann A, Dickson CJ, Arabin P, Zimmerlin A, Kiffe M, Froehlicher M, Boersig T, Elhajouji A, Brichet M, Menon S, Liu S, Mueller M, Wartchow CA, Lin J, Gloria YC, Dickhöfer S, Weber ANR, Welzel T, Kuemmerle-Deschner J, Farady CJ, Pulz R, Bornancin F, Buckley DL, Bassi ZI. A cereblon-based glue degrader of NEK7 regulates NLRP3 inflammasome in a context-dependent manner. Cell Chem Biol. 2025. 32:955-968.e13. PMID: 40639372.

Leal VNC, Bork F, Mateo Tortola M, von Guilleaume JC, Greve CL, Bugl S, Danker B, Bittner ZA, Grimbacher B, Pontillo A, Weber ANR. Bruton's tyrosine kinase (BTK) and matrix metalloproteinase-9 (MMP-9) regulate NLRP3 inflammasome-dependent cytokine and neutrophil extracellular trap responses in primary neutrophils. J Allergy Clin Immunol. 2025. 155:569-582. PMID: 39547282.

Wilhelmsen K, Deshpande A, Tronnes S, Mahanta M, Banicki M, Cochran M, Cowdin S, Fortney K, Hartman G, Hughes RE, Montgomery R, Portillo CP, Rubin P, Salazar T, Wang Y, Yan S, Morgan BA, Duisembekova A, Riou R, Marleaux M, Hochheiser IV, Buthmann H, Ferber D, Torp J, Wang W, Cranston M, McKee CM, Mawhinney TJ, McKay EC, Eroglu FK, Kümmerle-Deschner J, Weber ANR, Py BF, Geyer M, Coll RC. Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action. J Exp Med. 2025. 222:e20242403. PMID: 40892070.

Engels P, Szolek A, Hörner S, Syrigos GV, Hebbel K, Schmidtke M, Zhou M, Mateo-Tortola M, Schönfeld C, Stefanczyk SA, Wolter K, Babaei S, Schindler M, Claassen M, Dauch D, Zender L, Tapía-Abellán A, Weber ANR. Actionable heterogeneity of hepatocellular carcinoma therapy-induced senescence. Cancer Immunol Immunother. 2025. 74:207. PMID: 40374812.

Li N, Deshmukh MV, Sahin F, Hafza N, Ammanath AV, Ehnert S, Nüssler A, Weber ANR, Jin T, Götz F. Staphylococcus aureus thermonuclease NucA is a key virulence factor in septic arthritis. Commun Biol. 2025. 8(1):598. PMID: 40210969.

Wolf J, Kusche Y, Eroglu FK, Kümmerle-Deschner J, Vogl T, Fritz G, Weber ANR, Jorch SK, Roth J, Austermann J. S100A9 promotes inflammasome-dependent autoinflammation by blocking the degradation of SYK tyrosine kinase. J Leukoc Biol. 2025. 117:qiaf129. PMID: 40966542.

Chang TH, Cardona Gloria Y, Hellmann MJ, Richardo T, Greve CL, Le Roy D, Roger T, Bork F, Bugl S, Jakob J, Sonnberger J, Kasper L, Hube B, Pusch S, Gow NAR, Sørlie M, Tøndervik A, Moerschbacher BM, Weber ANR. Transkingdom mechanism of MAMP generation by chitotriosidase feeds oligomeric chitin from fungal pathogens and allergens into TLR2-mediated innate immune sensing. Front Immunol. 2025. 16:1497174. PMID: 40098951.

2024

Bork F, Greve CL, Youn C, Chen S, N C Leal V, Wang Y, Fischer B, Nasri M, Focken J, Scheurer J, Engels P, Dubbelaar M, Hipp K, Zalat B, Szolek A, Wu MJ, Schittek B, Bugl S, Kufer TA, Löffler MW, Chamaillard M, Skokowa J, Kramer D, Archer NK, Weber ANR. naRNA-LL37 composite DAMPs define sterile NETs as self-propagating drivers of inflammation. EMBO Rep. 2024. 25(7):2914-2949. PMID: 38783164.

Knopp T, Jung R, Wild J, Bochenek ML, Efentakis P, Lehmann A, Bieler T, Garlapati V, Richter C, Molitor M, Perius K, Finger S, Lagrange J, Ghasemi I, Zifkos K, Kommoss KS, Masri J, Reißig S, Randriamboavonjy V, Wunderlich T, Hövelmeyer N, Weber ANR, Mufazalov IA, Bosmann M, Bechmann I, Fleming I, Oelze M, Daiber A, Münzel T, Schäfer K, Wenzel P, Waisman A, Karbach S. Myeloid cell-derived interleukin-6 induces vascular dysfunction and vascular and systemic inflammation. Eur Heart J Open. 2024. 4(4):oeae046. PMID: 39015379.

Weber ANR, Tortola MM, Kuemmerle-Deschner JB. Cracking the NLRP3 code: Pioneering precision medicine for inflammation. J Exp Med. 2024. 221(5):e20240221. PMID: 38536100.